Table 2.
Hospital mortality of patients with acute respiratory distress syndrome, with or without severe acute cor pulmonale
| Hospital mortality | All ARDS patients (N = 234) | ARDS patients without severe ACP (N = 168) | ARDS patients with severe ACP (N = 66) | P valueb |
|---|---|---|---|---|
| Severity of ARDSa (%, CI) | ||||
| Mild | 17/83 (20.5, 12.4–30.8) | 10/59 (17.0, 8.4–29.0) | 7/24 (29.2, 12.6–51.1) | 0.239 |
| Moderate | 36/108 (33.3, 24.6–43.1) | 22/79 (27.9, 18.3–39.1) | 14/29 (48.3, 29.4–67.5) | 0.065 |
| Severe | 22/43 (51.2, 35.5–66.7) | 15/30 (50.0, 31.3–68.7) | 7/13 (53.8, 25.1–80.8) | 1.000 |
| Overall cohort (%, CI) | 75/234 (32.1, 26.1–38.4) | 47/168 (28.0, 21.3–35.4) | 28/66 (42.4, 30.3–55.2) | 0.043* |
ACP Acute cor pulmonale (severe ACP is defined as right ventricular dilatation with the right-to-left ventricular size ratio ≥ 1 in end diastole at the papillary muscle level and interventricular septal straightening/paradoxical motion), ARDS acute respiratory distress syndrome, CI 95% confidence interval
*P < 0.05
aARDS severity according to the Berlin Definition: mild (PF ratio 201–300 mmHg), moderate (PF ratio 101–200 mmHg) and severe (PF ratio 100 mmHg or less), where PF ratio is the ratio of arterial oxygen partial pressure (mmHg) to inspired oxygen fraction
bComputed for the mortality difference between patients with and without severe acute cor pulmonale, using the Fisher exact test