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Contrast-enhanced MRI and db-PEM images of a patient with a large multi-focal breast cancer with greatest extend measured at 6.8 cm. The db-PET images acquired with the standard aperture (a) only show the anterior portion of the lesion, with an extent of 4.4 cm. With the large 220-mm aperture (b), there is more complete visualization of tumor extent (maximum extent of 6.1 cm) that closely matches that seen on the MRI
