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. 2017 Dec 15;8:1837. doi: 10.3389/fimmu.2017.01837

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Copyright © 2017 Ghazarian, Caillat-Zucman and Houdouin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maturation, proliferation, and migration of mucosal-associated invariant T (MAIT) cells. MAIT cells have a naive phenotype (CD45RA^high/CD27/CD45RO^lo) and a low frequency in cord blood compared with adult peripheral blood. Classically, MAIT cell development in the thymus is divided into three stages defined by their expression of CD161 and CD27, with stage 3 MAIT cells resembling MAIT cells found in peripheral blood after birth. After the birth, MAIT cells proliferate and acquire a mature phenotype. The colonization of different organs starts already during fetal development.