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. 2017 Dec 15;8:1673. doi: 10.3389/fimmu.2017.01673

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Copyright © 2017 Zaghloul, Addorisio, Silverman, Patel, Valdés-Ferrer, Ayasolla, Lehner, Olofsson, Nasim, Metz, Wang, Ahmed, Chavan, Diamond, Tracey and Pavlov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cecal ligation and puncture (CLP)-sepsis alters circulating cytokine levels and suppresses LPS-induced immune responsiveness. (A) Increased serum cytokine levels in mouse sepsis survivors 14 days after CLP or sham surgery. **P = 0.0092, ***P = 0.0004 (TNF), ***P = 0.0002 (IL-1b, IL-10), ****P = 0.0001, Student’s t-test, n = 7–9 per group. (B) Sepsis survivors exhibit reduced LPS-induced serum TNF levels during endotoxemia when compared to sham controls. ***P = 0.001, Student’s t-test, n = 8–9 per group.