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. 2017 Dec 15;8:1673. doi: 10.3389/fimmu.2017.01673

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Copyright © 2017 Zaghloul, Addorisio, Silverman, Patel, Valdés-Ferrer, Ayasolla, Lehner, Olofsson, Nasim, Metz, Wang, Ahmed, Chavan, Diamond, Tracey and Pavlov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cecal ligation and puncture (CLP) has a significant impact on basal forebrain cholinergic balance in sepsis survivors. (A) Representative images of choline acetyltransferase (ChAT) immunostaining in the basal forebrain of sham and CLP mice (scale bar = 100 μm). (B) Quantitative analysis of ChAT immunostaining in the basal forebrain of sham and CLP mice. *P = 0.0229, Student’s t-test, n = 5 per group. (C) Acetylcholinesterase (AChE) activity in cortex and hippocampus of sham and CLP mice. ***P = 0.0004, Student’s t-test, n = 8 per group. (D) Relative Ache mRNA expression in cortex and hippocampus of sham and CLP mice. **P = 0.0052, Student’s t-test, n = 8 per group. (E) Relative Chrm1 mRNA expression in cortex and hippocampus of sham and CLP mice. *P = 0.0481, Student’s t-test, n = 8 per group.