Table 2.
Clinicopathological characteristics of FFPE prostate tissue samples obtained for HOXB13 G84E carriers and non-carriers.
| PcTas ID | Age at Diagnosis | Tissue Source | Germline Genotype | Tumour Genotype | Tumour Grade1 | Contemporary Gleason Score2 |
|---|---|---|---|---|---|---|
| PcTas4–3 | 80 | TURP | CC | CC | M/PD | 7 (4 + 3) |
| PcTas11–11 | 85 | TURP | N/A | CC | — | 7 (3 + 4) |
| PcTas11–12 | 58 | TURP | N/A | CC | — | 9 (4 + 5) |
| PcTas11–13 | 72 | TURP | N/A | CC | — | No tumour |
| PcTas11–16 | 78 | TURP | N/A | CC | — | 5 (2 + 3) |
| PcTas12–1 | 63 | RP | CC | CC | MD | 6 (3 + 3) |
| PcTas12–6 | 80 | TURP | N/A | CC | PD | 7 (3 + 4) |
| PcTas12–9 | 68 | TURP | N/A | CC | — | 6 (3 + 3) |
| PcTas22–6 | 63 | TURP | CC | CC | WD | No tumour |
| PcTas47–2 | 68 | TURP | CC | CC | WD | No tumour |
| PcTas60–1 | 58 | TURP | CC | CC | WD | 6 (3 + 3) |
| PcTas63–24 | 67 | TRUS | N/A | CC | MD | 6 (3 + 3) |
| PcTas72–4 | 70 | TURP | CC | CC | PD | 9 (4 + 5) |
| PcTas12–3 | 62 | TURP | N/A | CT | WD | 4 (2 + 2) |
| PcTas12–7 | 59 | TURP | N/A | CT | PD | 9 (4 + 5) |
| PcTas12–8 | 73 | TURP | N/A | CT | — | 6 (3 + 3) |
| PcTas22–203 | 79 | TRUS | CC | CT | PD | 8 (4 + 4) |
| PcTas22–576 | 69 | RP | N/A | CT | M/PD | 7 (3 + 4) |
| PcTas22–637 | 70 | TRUS | CT | CT | PD | 8 (4 + 4) |
| PcTas72–6 | 62 | TURP | CT | CT | W/MD | 5 (3 + 2) |
| PcTas72–154 | 63 | TRUS | CT | CT | WD | 4 (2 + 2) |
| PcTas3250–1 | 51 | RP | CT | CT | PD | 9 (4 + 5) |
1Tumour grade obtained from pathology report.
2Contemporary Gleason Score from FFPE tissue block chosen for macrodissection of nucleic acids and IHC. N/A: germline sample not available. WD: well differentiated. MD: moderately differentiated; PD. poorly differentiated. -: Information not present in original pathology report.