Fig. 3.

Prevention of mitochondrial damage induced by rotenone. Some of the generic drugs that prevented against iron-mediated neurotoxicity were tested against mitochondrial damage to neurons. Some compounds, such as indapamide, prevented mitochondrial damage as shown after normalization to the control neurons (a). However, the rescue effect was small. Treatment with rotenone induced marked morphological changes with retraction of cell processes (b). The scale bar shows 100 µM. Shown are normalized data of mean ± SEM of 1–3 experiments each performed in quadruplicates. Two-way ANOVA with Bonferroni multiple comparisons test as post hoc analysis vs. rotenone: *p < 0.05; ****p < 0.0001