Table 2.
Differential significant metabolites identified in the cells and secretome of the breast cancer cell lines to discriminate BRCA1-like and non BRCA1-like breast cancer profile.
| Metabolite | m/z | RT (sec) | Cell Pellet | Secretome | Formula | ||
|---|---|---|---|---|---|---|---|
| P. adj value | FC | P. adj value | FC | ||||
| Adenine | 136.0612 | 263.7 | 3.4E-03 | −2.61 | 1.2E-01 | 3.10 | C10H13N5O4 |
| Arginine-Aspartate | 290.1439 | 65.1 | 2.9E-03 | −3.71 | ND | ND | C10H19N5O5 |
| Folic Acid | 442.1441 | 295.5 | 8.8E-04 | −17.4 | 3.6E-14 | −3.6 | C19H19N7O6 |
| Guanosine | 284.0804 | 243.3 | 2.4E-03 | −2.28 | ND | ND | C10H13N5O5 |
| Methyladenosine | 282.1178 | 261.1 | 8.4E-03 | −5.52 | 8.4E-04 | −3.6 | C11H15N5O4 |
| Methylguanine | 166.0712 | 222.5 | 1.7E-02 | −1.68 | 1.5E-05 | −3.7 | C6H7N5O |
| Phenylacetylglycine | 194.0801 | 348.6 | 3.2E-04 | −5.09 | 8.8E-10 | −2.3 | C10H11NO3 |
| Thiamine pyrophosphate | 425.0413 | 65.8 | 5.8E-03 | −2.64 | 2.7E-16 | −2.9 | C12H18N4O7P2S |
| Uridine | 243.0636 | 190.6 | 2.4E-03 | −4.29 | ND | ND | C9H12N2O6 |
m/z: mass to charge ratio; RT: retention time; FC: fold change expressed as log2; ND: not detected.