Table 3.
Candidate metabolites analysed to discriminate BRCA1-like breast cancer profile in plasma samples of HBOC patients.
| Metabolite | TN HBOC BRCA1 mutated | TN HBOC BRCA1 wt | P. adj value | ||
|---|---|---|---|---|---|
| Mean | SD | Mean | SD | ||
| Adenine | 0.32 | 0.19 | 0.56 | 0.42 | 0.033* |
| Arginine-Aspartate | ND | ND | ND | ND | ND |
| Folic Acid | 0.04 | 0.05 | 0.02 | 0.02 | 0.41 |
| Guanosine | 0.51 | 0.21 | 0.58 | 0.78 | 0.10 |
| 1-Methyladenosine | 34.18 | 7.81 | 35.35 | 9.24 | 0.76 |
| N6-Methyladenosine | 0.42 | 0.35 | 0.78 | 0.42 | 0.012* |
| 1-Methylguanine | 0.56 | 0.29 | 0.76 | 0.33 | 0.033* |
| 7-Methylguanine | 9.32 | 1.85 | 9.15 | 2.14 | 0.55 |
| Phenylacetylglycine | 1.60 | 2.55 | 2.47 | 2.64 | 0.18 |
| Thiamine pyrophosphate | ND | ND | ND | ND | ND |
| Uridine | 680.67 | 262.85 | 614.48 | 273.78 | 0.41 |
TN: triple negative; HBOC: hereditary breast and ovarian cancer; wt: wild-type; SD: standard deviation; ND: not detected; * Statistically significant (p value < 0.05).