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. 2017 Dec 19;8:2127. doi: 10.1038/s41467-017-02178-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commonslicense, unless indicated otherwise in a credit line to the material. If material is not included in the article’sCreative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Unsupervised clustering reveals three distinct clusters of DNA methylation in patients with JMML. Thirty-nine patients who underwent Illumina 450k analysis are included. Patients are displayed on the X axis and the 1527 most variable CpG sites (top 0.5% ranked by standard deviation) are displayed on the Y axis. The three most significant patient characteristics in univariable analysis are presented at the top of the figure. HgB F fetal hemoglobin, SR spontaneous resolution, EFS event-free survival, β beta value, N/A not available