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. 2017 Dec 19;8:2127. doi: 10.1038/s41467-017-02178-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commonslicense, unless indicated otherwise in a credit line to the material. If material is not included in the article’sCreative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — DNA methylation predicts outcome in an independent cohort. Forty patients from EWOG-MDS were analyzed. Patients are displayed on the X axis and the same 1527 most variable CpG sites from the unsupervised discovery cohort analysis are displayed on the Y axis. Patients are assigned a cluster designation based on minimum distance to the centroid of the discovery cohort clusters. HgB F fetal hemoglobin, SR spontaneous remission, EFS event-free survival, β beta value