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. 2017 Dec 19;7:17808. doi: 10.1038/s41598-017-18257-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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INTEGRATE-Vis output illustrated using the TMPRSS2-ERG gene fusion in prostate cancer. INTEGRATE-Vis outputs four visualizations including: (A) gene fusion transcript isoforms, (B) the predicted protein structure of the gene fusion, (C) RNA-Seq read coverage across each gene fusion partner to reveal changes in exon expression (A red line is plotted at the fusion junctions at both gene partners. Exon boundaries are represented by blue lines. A marked expression change occurs between exons 3 and 4 of ERG.), and (D) expression of each gene fusion partner across the TCGA PRAD cohort. Blue is used to represent supporting reads, exons, transcript, and genomic locations for the 5′ gene partner (TMPRSS2), while red is for those of the 3′ gene partner (ERG).