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. 2017 Dec 19;8:2175. doi: 10.1038/s41467-017-02184-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Confocal images from the interaction of two individual malignant cell samples by HUVEC traps. Retraction of the membrane and signs of membrane blebbing could be observed. b Similar images were taken from the interaction of non-malignant lymph nodes and HUVECs, and no retraction was observed in the structure of interacted HUVECs. c Migration and diffusion of a non-malignant blood cell, derived from a healthy donator, into the HUVEC trap. d The trace of the hole produced by transcellular migration of leukocytes could be observed. e Similar confocal images from non-retracted endothelial layer after TC of blood immune cells . f Attachment of an immunocell existed in a non-malignant lymph node to the HUVEC. Note: all of the images were taken after at least 6 h of interaction between the cells and HUVECs. g Geimsa staining image taken after 7 h of interaction between WBCs (of a healthy donator) and HUVECs. Optical time-lapse images of h non-metastatic lymph; i healthy blood; and j metastatic lymph samples in interaction with single HUVECs. HUVEC retraction and membrane blebbing was only induced by the metastatic cell (i). Related Supplementary Movies: g Supplementary Movie 6 h Supplementary Movie 7 i Supplementary Movie 8. The scale bars are 25 µm in length