. 2017 Dec 19;7:17805. doi: 10.1038/s41598-017-18233-w

Table 2.

Univariate analysis of OS and CSS.

Variables		N	OS		CSS
Variables		N	3 year rate [95% CI]	p value*	3 year rate [95% CI]	p value*
Site of primary lesion	oropharynx	141	0.667 [0.576–0.744]	0.685	0.723 [0.632–0.795]	0.708
Site of primary lesion	hypopharynx	135	0.672 [0.574–0.752]	0.685	0.734 [0.638–0.808]	0.708
Age	≤65 years	148	0.697 [0.608–0.769]	0.066	0.759 [0.672–0.825]	0.098
Age	>65 years	128	0.638 [0.537–0.722]	0.066	0.690 [0.589–0.771]	0.098
Gender	Female	23	0.807 [0.563–0.923]	0.306	0.848 [0.596–0.949]	0.379
Gender	Male	253	0.657 [0.588–0.717]	0.306	0.717 [0.649–0.774]	0.379
KPS	≥90%	205	0.699 [0.625–0.761]	< 0.001	0.752 [0.680–0.811]	0.002
KPS	<90%	71	0.582 [0.439–0.701]	< 0.001	0.656 [0.508–0.770]	0.002
Current smoker	No	157	0.732 [0.644–0.801]	0.005	0.787 [0.701–0.851]	0.007
Current smoker	Yes	119	0.590 [0.490–0.677]	0.005	0.650 [0.548–0.735]	0.007
Smoking history	< 10 packs year	68	0.769 [0.633–0.860]	0.012	0.829 [0.696–0.908]	0.011
Smoking history	≥ 10 packs year	208	0.639 [0.563–0.706]	0.012	0.697 [0.621–0.760]	0.011
T stage	123	233	0.671 [0.600–0.733]	0.031	0.736 [0.666–0.794]	0.014
T stage	4	43	0.668 [0.496–0.792]	0.031	0.690 [0.517–0.812]	0.014
N stage	0	86	0.774 [0.656–0.856]	0.054	0.869 [0.761–0.930]	0.005
N stage	123	190	0.624 [0.544–0.694]	0.054	0.666 [0.585–0.735]	0.005
Hemoglobin Concentration	≤11g/dL	31	0.612 [0.408–0.764)]	0.110	0.797 [0.572–0.912]	0.612
Hemoglobin Concentration	>11g/dL	245	0.678 [0.608–0.737]	0.110	0.721 [0.653–0.778]	0.612
CRP	≤ 0.3 mg/dl	144	0.756 [0.668–0.823]	0.005	0.801 [0.716–0.862]	< 0.001
CRP	>0.3 mg/dl	132	0.575 [0.477–0.662]	0.005	0.646 [0.545–0.730]	< 0.001
IMRT	No	223	0.676 [0.605–0.736]	0.334	0.731 [0.662–0.789]	0.445
IMRT	Yes	53	0.655 [0.468–0.789]	0.334	0.728 [0.543–0.847]	0.445
Radiation fractionation	Once-daily	244	0.664 [0.594–0.725]	0.704	0.730 [0.662–0.787]	0.795
Radiation fractionation	Other regimen*	32	0.719 [0.515–0.849]	0.704	0.719 [0.515–0.849]	0.795
Neck dissection	No	235	0.676 [0.606–0.736]	0.857	0.732 [0.663–0.788]	0.889
Neck dissection	Yes	41	0.630 [0.432–0.775]	0.857	0.698 [0.489–0.835]	0.889
Induction chemotherapy	No	182	0.645 [0.562–0.717]	0.046	0.701 [0.618–0.769]	0.139
Induction chemotherapy	Yes	94	0.713 [0.602–0.799]	0.046	0.776 [0.668–0.853]	0.139
Concurrent chemotherapy	No	164	0.697 [0.611–0.767]	0.263	0.759 [0.675–0.824]	0.140
Concurrent chemotherapy	Yes	112	0.632 [0.527–0.720]	0.263	0.683 [0.577–0.768]	0.140

*Other regimens include twice-daily and concomitant boost radiotherapy.