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. 2017 Dec 19;7:17775. doi: 10.1038/s41598-017-18195-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of the whole transcriptome regulation in our primary cohort. (a) Differentially expressed union 2565 genes’ profiles for 6 acute infectious mononucleosis (AIM), 5 chronic active EBV infection (CAEBV) and 6 healthy control subjects. The Venn diagram depicts how many genes were differentially expressed in each comparison and how many genes overlapped between comparisons. Intensity values were normalized by quantile across samples and by z-score across genes. In the heatmap, each row represents a gene and each column represents a sample, with the 17 samples labeled at the bottom. (b) Significantly enriched KEGG pathways. Each pathway is labeled by KEGG pathway ID and name. The number of genes in a pathway is given in parenthesis. Solid bars are for AIM, and open bars are for CAEBV. Up-regulation is marked with red and down with blue. The p-value reflects the level of confidence for enrichment significance; and the enrichment score is an equivalent to the t value in a Student t-test and can be a gauge for the degree of pathway dysregulation.