Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 19;7:17775. doi: 10.1038/s41598-017-18195-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Key genes defined through whole transcriptome profiling analysis. (a) Hypoactive and (b) hyperactive genes identified in patients with acute EBV infection (AIM) in our primary cohort. The expression levels of the 61 genes were highly correlated with those of blood immune cell markers at Pearson correlation coefficient >= 0.8 and their fold-changes were at least 1.5 fold below (panel A: hypoactive) or above (panel B: hyperactive) the fold-changes of a cell marker gene. The model cell markers (CD11c, CD114, CD8a, and CD94) were selected based upon the level of their overall correlation with individual genes. (c) Unique dysregulated genes (n = 102) in chronic active EBV infection (CAEBV). These genes were differentially expressed in CAEBV but not in AIM. There were 30 protein coding genes with absolute fold-change values greater than 1.75 at adjusted p < 0.05. Most of these up-regulated genes (15/22) were highly correlated with monocyte markers CD64A/B (FCGR1A/B) and CD14. Most of down-regulated genes (6/8) were correlated with EBV targeting B cell markers CD19/20/22.