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. 2017 Dec 19;7:17765. doi: 10.1038/s41598-017-18130-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Afh mutants show lengthening of work-for-food circadian period. (a) Double plotted actograms of the nose-poke activity for a wild type (left panel) and the Afh homozygous mouse (right panel). The gray shadowed region represents the dark phase in LD condition and is followed by DD. Vertical black bars describe bouts of nose-poking activity for 15 min. bin. (a) Mean ± SEM period during LD (white histogram) and DD (gray histogram) for +/+ (n = 6; LD: 24.1 ± 0.32, DD: 24.2 ± 0.07) and Afh/Afh (n = 6; LD: 23.9 ± 0.31, DD: 26.8 ± 0.68) mice. (**p < 0.005 One-way ANOVA). (c) A measure of the period strength for wild type (black line) and homozygous (gray line) mutant mice in LD (left panel) and DD (right panel) phases. Mean ± SEM distributions of the correlation coefficient between periodic fit and actograms for increasing values of period. (c) The alpha represents the length of the segment of the daily activity.