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. 2017 Dec 19;7:17765. doi: 10.1038/s41598-017-18130-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Interval Timing is disrupted in Afh mutants. (a) Graphical representation of the fixed-interval and peak-interval task. A nose poke in the central hopper activates a light signal (2 sec) and after 10 sec. the mouse receives a food pellet at the lateral hopper if it nose pokes before a time limit of 30 sec. In probe (PI) trials no pellet is dispensed. Probe (PI) trials are presented with a probability of 0.2. (b) Representative response curve gathered from probe trials. The increase of nose pokes around the target time reflects the trial time at which the animal’s expectancy of the reward delivery is maximal. The Peak times (mean ± SEM) in the timing task are shown for wild-type (n = 6) mice (blue) and for Afh (n = 6) mutants (red) over 5 consecutive days (left panel) and overall (right panel) in LD (c) and DD (d). Peak times (mean ± SEM) for the two-interval experiment are plotted over 6 days (left panel) and overall (right panel) in LD (e) and in the T-cycle (f) condition.