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. 2017 Dec 19;7:17837. doi: 10.1038/s41598-017-16224-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Networks of the DEGs in hMSCs/inv. (a) Network of the DEGs in young hMSCs/inv compared with young hMSCs/n. (b) SPP1, CXCL12, SFRP1, and NCAM1 are the triangle nodes identified as bottlenecks. (c) Network of the DEGs in senescent hMSCs/inv compared with senescent hMSCs/n. (d) EGF is the triangle node identified as a bottleneck. The red and green colors represent upregulated and downregulated genes in hMSC/inv, respectively.