Table 1.
Genes unique to Listeria sensu stricto strains and absent in Listeria sensu lato strains.
| gene name/lmo number | Function, protein name, or protein homology/similarity to | COG number | Gene name/lmo number | Function, protein name, or protein homology/similarity to | COG number |
|---|---|---|---|---|---|
| Metabolism | Miscellaneous | ||||
| lmo0661 | Carboxymuconolactone decarboxylase family protein involved in protocatechuate catabolism | COG0599 | lmo0090, 0091, 0093 | ATP synthase α-/γ-chain, ε-subunit; upregulated in Caco-2 cells and relevant for intracellular replication44,62 | COG0056, 0224, 0355 |
| cobU-pduO (lmo1141-1142, 1146-1148, 1169, 1190-1199,1203-1209) | Cobalamin biosynthesis | COG2087 | pdeD (lmo0111) | c-di-GMP-specific phosphodiesterase, EAL domain | COG2200 |
| pduS-pduQ (lmo1143-1145, 1151-1171) | 1,2-PD degradation pathway | COG4656 | lmo0368 | Putative Nudix hydrolase YfcD catalyzing the hydrolysis of nucleoside diphosphates | COG1443 |
| eutA-eutQ (lmo1174-1187) | Ethanolamine utilization pathway | COG4819 | lmo0481 | Myosin-Cross-Reactive Antigen, oleate hydratase; upregulated in vivo 87 | COG4716 |
| Cell motility and chemotaxis | lmo0511 | Glutamine amidotransferase; DegU regulated | COG0518 | ||
| fliN–fliS (lmo0675-lmo0718) | Flagellar biosynthesis | — | lmo0617 | Putative lipoprotein with DUF4352 domain, immunoprotective extracellular protein0212 | — |
| lmo0723, lmo1699 | Methyl-accepting chemotaxis proteins | COG0840 | lmo0625 | Lipolytic protein GDSL family | COG2755 |
| Cell wall/membrane/envelope biogenesis | lmo0635 | 2-Haloalkanoic acid dehalogenase with phosphatase activity | COG1011 | ||
| lmo0703 | UDP-N-acetylenolpyruvoylglucosamine reductase involved in peptidoglycan biosynthesis; regulated by DegU and MogR88,89 | COG1728 | lmo1415 | Hydroxymethylglutaryl-CoA synthase involved in isopentenyl pyrophosphate synthesis via the mevalonate pathway; possibly influences Vγ9/Vδ2 T cells90 | COG3425 |
| lmo0717 | Murein transglycosylase with N-acetyl-D-glusoamine binding site, SLT family; DegU and MogR regulated88,89 | COG0741 | lmo1638 | Microcin C7 self-immunity protein MccF; its absence results in listerial accumulation in the liver91 | COG1619 |
| lmo0724 | Peptidase | COG4990 | lmo2424 | Thioredoxin | COG3118 |
| Transporter | No orthologues | ||||
| lmo0269 | Oligopeptide transport system permease protein | COG1173 | lmo0615 | Hypothetical protein | — |
| lmo0987 | ABC transporter, permease protein, induced in CodY mutant92; related to CylB of Streptococcus agalactiae involved in hemolysin production | COG1511 | lmo0622 | Hypothetical protein | — |
| lmo1131, 1132 | ABC transporter, ATP-binding/permease protein | COG4988 | lmo0657 | Hypothetical protein | — |
| lmo2181 | NPQTN specific sortase B; surface protein transpeptidase involved in anchoring of SvpA and Hbp1 | COG4509 | lmo0793 | Putative transport protein | COG1811 |
| svpA/hbp2(lmo2185), hbp1 (lmo2186) | NPQTN cell wall anchored proteins with similarity to IsdA, IsdC of Staphylococcus aureus 93; heme-binding NEAT domain associated with iron/heme transport94; Fur and MecA regulated virulence factor42,43 | COG5386 | lmo0819 | Hypothetical protein | — |
| lmo2669 | Type IV ABC-transporter, upregulated under anaerobic conditions80 | COG4905 | lmo1626 | Hypothetical protein | — |
| Transcription | lmo1779 | Hypothetical protein | — | ||
| lmo0212 | Acetyltransferase, GNAT family | COG0456 | lmo2063 | Hypothetical protein | — |
| lmo1309, 1310 | Co-activators of prophage gene expression IbrB, IbrA | COG1475, COG3969 | lmo2065 | Hypothetical protein | — |
| lmo1311 | SNF2 family domain protein | COG0553 | lmo2066 | Hypothetical protein | — |
| lmo2234 | Sugar phosphate isomerase | COG1082 | lmo2169 | Hypothetical protein | — |
| lmo2432 | Hypothetical protein; Fur-box43 | — | |||
| lmo2803 | Hypothetical protein | — | |||
| lmo2843 | Hypothetical protein | COG5279 | |||