Table 2.

Meta-analysis of the association between genetic polymorphisms of PTEN/AKT/mTOR pathway and cancer risk.

Variables	No. of cases/controls	P z*	Homozygous OR(95% CI)	P het#	I 2# (%)	P z*	Heterozygous OR(95% CI)	P het#	I 2# (%)
mTOR rs2295080			GG vs. TT				TG vs. TT
Urinary system cancer†	4203/4392	0.029	0.78(0.62, 0.97)	0.978	0.0	0.000	0.77(0.69, 0.85)	0.999	0.0
Blood system cancer§	5971/1146	0.003	2.25(1.33, 3.82)	0.264	24.8	0.574	1.07(0.86, 1.33)	0.691	0.0
Digestive system cancer¶	3605/3747	0.001	0.56(0.40, 0.79)	0.481	0.0	0.006	0.81(0.70, 0.94)	0.707	0.0
Overall	8965/9868	0.456	0.89(0.65, 1.22)	0.001	69.2	0.000	0.82(0.76, 0.89)	0.465	0.0
mTOR rs2536			CC vs. TT				TC vs. TT
Urinary system cancer	3090/3279	0.954	1.02(0.56, 1.86)	0.976	0.0	0.729	0.95(0.69, 1.29)	0.001	81.0
Digestive system cancer	417/554	0.975	0.99(0.64, 1.53)	0.97	0.0	0.473	1.04(0.93, 1.17)	0.789	0.0
Blood system cancer	4344/4421	0.181	2.59(0.64, 10.43)	—	—	0.245	0.82(0.58, 1.15)	—	—
Overall	8411/8837	0.555	1.10(0.80, 1.53)	0.968	0.0	0.998	1.00(0.89, 1.13)	0.022	53.7
pTEN rs701848			CC vs. TT				TC vs. TT
Oral cavity cancer¥	331/356	0.359	0.81(0.53, 1.26)	0.312	16.0	0.292	0.82(0.57, 1.18)	0.603	0.0
Digestive system cancer	2418/2662	0.000	1.51(1.24, 1.84)	0.037	57.7	0.000	1.36(1.19, 1.57)	0.032	59.2
Urinary system cancer	2086/2228	0.001	1.33(1.12, 1.58)	0.561	0.0	0.049	1.14(1.00, 1.31)	0.539	0.0
Overall	5882/6284	0.000	1.35(1.21, 1.51)	0.019	48.1	0.000	1.21(1.11, 1.32)	0.050	40.9
AKT1 rs2494750			CC vs. GG				GC vs. GG
Urinary system cancer	2086/2228	0.830	0.97(0.76, 1.24)	0.671	0.0	0.050	3.60(1.00, 12.97)	0.000	96.0
Reproductive system cancer$	30/30	0.621	0.93(0.70, 1.24)	—	—	0	0.01(0.01, 0.03)	—	—
Digestive system cancer	2216/2240	0.264	1.13(0.91, 1.41)	0.304	5.3	0.292	1.31(0.79, 2.17)	0.000	97.5
Overall	4332/4498	0.727	1.03(0.89, 1.18)	0.658	0.0	0.943	1.03(0.49, 2.17)	0.000	97.5
AKT1 rs2494752			GG vs. AA				AG vs. AA
Digestive system cancer	2217/2240	0.397	1.10(0.88, 1.38)	0.273	16.8	0.151	1.10(0.97, 1.24)	0.137	54.8
Other cancer	970/934	0.098	1.26(0.96, 1.66)	—	—	0.057	1.22 (0.99, 1.48)	—	—
Overall	3187/3174	0.090	1.16(0.96, 1.38)	0.412	0.0	0.026	1.13(1.01, 1.25)	0.228	32.4

^* P ^z: the significance of the pooled OR was determined by Z-test, and P < 0.05 was considered as statistically significant.

^# P ^het and I ² were calculated by Chi square-based Q-test.

^†Urinary system cancer: renal cancer, prostate cancer; ^§Blood system cancer: acute lymphocytic leukemia, acute myeloid leukemia; ^¶Digestive system cancer: gastric cancer, ESCC, hepatocellular cancer, colorectal cancer; ^¥Oral cavity cancer: laryngo cancer; ^$Reproductive system cancer: endometrial cancer.