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. 2017 Dec 19;7:17844. doi: 10.1038/s41598-017-17250-z

Table 2.

Meta-analysis of the association between genetic polymorphisms of PTEN/AKT/mTOR pathway and cancer risk.

Variables No. of cases/controls P z* Homozygous OR(95% CI) P het# I 2# (%) P z* Heterozygous OR(95% CI) P het# I 2# (%)
mTOR rs2295080 GG vs. TT TG vs. TT
Urinary system cancer 4203/4392 0.029 0.78(0.62, 0.97) 0.978 0.0 0.000 0.77(0.69, 0.85) 0.999 0.0
Blood system cancer§ 5971/1146 0.003 2.25(1.33, 3.82) 0.264 24.8 0.574 1.07(0.86, 1.33) 0.691 0.0
Digestive system cancer 3605/3747 0.001 0.56(0.40, 0.79) 0.481 0.0 0.006 0.81(0.70, 0.94) 0.707 0.0
Overall 8965/9868 0.456 0.89(0.65, 1.22) 0.001 69.2 0.000 0.82(0.76, 0.89) 0.465 0.0
mTOR rs2536 CC vs. TT TC vs. TT
Urinary system cancer 3090/3279 0.954 1.02(0.56, 1.86) 0.976 0.0 0.729 0.95(0.69, 1.29) 0.001 81.0
Digestive system cancer 417/554 0.975 0.99(0.64, 1.53) 0.97 0.0 0.473 1.04(0.93, 1.17) 0.789 0.0
Blood system cancer 4344/4421 0.181 2.59(0.64, 10.43) 0.245 0.82(0.58, 1.15)
Overall 8411/8837 0.555 1.10(0.80, 1.53) 0.968 0.0 0.998 1.00(0.89, 1.13) 0.022 53.7
pTEN rs701848 CC vs. TT TC vs. TT
Oral cavity cancer¥ 331/356 0.359 0.81(0.53, 1.26) 0.312 16.0 0.292 0.82(0.57, 1.18) 0.603 0.0
Digestive system cancer 2418/2662 0.000 1.51(1.24, 1.84) 0.037 57.7 0.000 1.36(1.19, 1.57) 0.032 59.2
Urinary system cancer 2086/2228 0.001 1.33(1.12, 1.58) 0.561 0.0 0.049 1.14(1.00, 1.31) 0.539 0.0
Overall 5882/6284 0.000 1.35(1.21, 1.51) 0.019 48.1 0.000 1.21(1.11, 1.32) 0.050 40.9
AKT1 rs2494750 CC vs. GG GC vs. GG
Urinary system cancer 2086/2228 0.830 0.97(0.76, 1.24) 0.671 0.0 0.050 3.60(1.00, 12.97) 0.000 96.0
Reproductive system cancer$ 30/30 0.621 0.93(0.70, 1.24) 0 0.01(0.01, 0.03)
Digestive system cancer 2216/2240 0.264 1.13(0.91, 1.41) 0.304 5.3 0.292 1.31(0.79, 2.17) 0.000 97.5
Overall 4332/4498 0.727 1.03(0.89, 1.18) 0.658 0.0 0.943 1.03(0.49, 2.17) 0.000 97.5
AKT1 rs2494752 GG vs. AA AG vs. AA
Digestive system cancer 2217/2240 0.397 1.10(0.88, 1.38) 0.273 16.8 0.151 1.10(0.97, 1.24) 0.137 54.8
Other cancer 970/934 0.098 1.26(0.96, 1.66) 0.057 1.22 (0.99, 1.48)
Overall 3187/3174 0.090 1.16(0.96, 1.38) 0.412 0.0 0.026 1.13(1.01, 1.25) 0.228 32.4

* P z: the significance of the pooled OR was determined by Z-test, and P < 0.05 was considered as statistically significant.

# P het and I 2 were calculated by Chi square-based Q-test.

Urinary system cancer: renal cancer, prostate cancer; §Blood system cancer: acute lymphocytic leukemia, acute myeloid leukemia; Digestive system cancer: gastric cancer, ESCC, hepatocellular cancer, colorectal cancer; ¥Oral cavity cancer: laryngo cancer; $Reproductive system cancer: endometrial cancer.