Table 1.
Characteristics of individuals studied.
| Characteristic | Total (n) | Genotype# | p value | ||
|---|---|---|---|---|---|
| 1a (n = 29) (%) | 2a (n = 88) (%) | 2b (n = 8) (%) | |||
| Gender | |||||
| Male | 73 | 17 (59) | 51 (58) | 5 (62.5) | 1* |
| Female | 52 | 12 (41) | 37 (42) | 3 (37.5) | |
| Age (months) | |||||
| Mean (SD) | NA | 130 (34) | 119 (32) | 138 (36) | 0.124§ |
| ABO blood group | |||||
| O | 68 | 16 (55) | 47 (53) | 5 (62.5) | 0.930* |
| A | 29 | 8 (28) | 19 (22) | 2 (25) | |
| B | 23 | 5 (17) | 17 (19) | 1 (12.5) | |
| AB | 5 | 0 (0) | 5 (6) | 0 (0) | |
| α+thalassaemia genotype‡ | |||||
| αα/αα | 49 | 12 (41) | 33 (38) | 4 (50) | 0.857* |
| −α/αα | 51 | 13 (45) | 35 (40) | 3 (37.5) | |
| −α/−α | 25 | 4 (14) | 20 (22) | 1 (12.5) | |
| Sickle cell (HbS) genotype‡ | |||||
| AA | 108 | 25 (86) | 77 (88) | 6 (75) | 0.547* |
| AS | 17 | 4 (14) | 11 (12) | 2 (25) | |
| CR1 copy number | |||||
| Mean (SD) | NA | 495 (204) | 478 (221) | 658 (305) | 0.098§ |
#1a = Sl1/Sl1, McC a/McC a genotype, 2a = Sl2/Sl2, McC a/McC a genotype, 2b = Sl2/Sl2, McC b/McC b genotype.
*Fisher’s exact test, §One-way ANOVA.
‡α+thalassaemia and sickle cell genotype were included in the study as both have previously been reported to influence CR1 copy number40,42,63.
SD, standard deviation. NA, not applicable.