Skip to main content
. 2017 Dec 19;7:17825. doi: 10.1038/s41598-017-17664-9

Table 3.

Effect of donor variables on cluster volume from mixed effects linear regression. The coefficient is the absolute change from the reference group.

Variable Mean cluster volume (µm3) SD Without adjustment for CR1 copy number With adjustment for CR1 copy number
Coefficient Standard error t value Coefficient Standard error t value
Combined genotype#
  1a 0.468 0.146 Reference NA NA Reference NA NA
  2a 0.476 0.127 0.012 0.029 0.400 0.016 0.022 0.717
  2b 0.502 0.160 0.035 0.054 0.658 −0.029 0.042 −0.708
Sl component alone
  Sl1/Sl1 0.468 0.146 Reference NA NA Reference NA NA
  Sl2/Sl2 0.478 0.130 0.014 0.029 0.475 0.012 0.022 0.552
McC component alone
  McC a /McC a 0.474 0.131 Reference NA NA Reference NA NA
  McC b /McC b 0.502 0.160 0.027 0.049 0.545 −0.041 0.038 −1.08
Gender
  Female 0.486 0.126 Reference NA NA Reference NA NA
  Male 0.468 0.137 −0.022 0.024 −0.895 −0.011 0.019 −0.584
ABO blood group
  O 0.469 0.137 Reference NA NA Reference NA NA
  A 0.476 0.100 0.008 0.030 0.264 0.029 0.023 1.275
  B 0.502 0.164 0.032 0.033 0.994 0.057 0.025 2.305
  AB 0.451 0.083 −0.022 0.063 −0.355 0.012 0.047 0.262
α+thalassaemia genotype
  αα/αα 0.493 0.139 Reference NA NA Reference NA NA
  −α/αα 0.475 0.136 −0.022 0.027 −0.805 −0.008 0.021 −0.401
  −α/−α 0.444 0.109 −0.051 0.033 −1.54 −0.017 0.026 −0.654
Sickle cell (HbS) genotype
  AA 0.472 0.133 Reference NA NA Reference NA NA
  AS 0.500 0.133 0.031 0.035 0.880 0.029 0.027 1.089
Age (years) Change in cluster volume with each additional year of age −0.002 0.004 −0.560 −0.005 0.003 −1.411
CR1 copy number Change in cluster volume with each additional 100 CR1 copies per cell NA NA NA 0.039 0.004 9.446

# 1a = Sl1/Sl1, McC a /McC a genotype, 2a = Sl2/Sl2, McC a /McC a genotype, 2b = Sl2/Sl2, McC b /McC b. SD, standard deviation. NA, not applicable.