Table III.
In vitro Permeability in Airway Cell Layers. Data Represent Mean ± SEM (n = 6, n = 36 for Mannitol) in Calu-3 and 16HBE14o- and Mean ± SD (n = 3, n = 18 for Mannitol) in NHBE
| Papp (10−6 cm/s) | |||
|---|---|---|---|
| Calu-3 | 16HBE14o- | NHBE | |
| Dextran 10 K | 0.2 ± 0.0 | 1.0 ± 0.1 | 0.7 ± 0.1 |
| Mannitol | 0.5 ± 0.1 | 3.7 ± 0.5 | 1.6 ± 0.5 |
| Terbutaline | 7.3 ± 0.4 | 19.3 ± 2.0 | 13.8 ± 0.8 |
| Formoterol | 6.4 ± 0.3 | 11.7 ± 0.8 | 8.2 ± 0.8 |
| Metoprolol | 10.3 ± 0.0 | 24.5 ± 2.5 | 11.3 ± 0.7 |
| Propranolol | 7.0 ± 0.4 | 17.3 ± 0.8 | 16.8 ± 3.0 |
| Imipramine | 5.2 ± 0.0 | 12.0 ± 0.9 | 12.5 ± 0.9 |