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. 2017 May 24;34(12):2466–2476. doi: 10.1007/s11095-017-2176-5

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Median morphology parameters of untreated and amiodarone-treated rat and human macrophage cell models. Median cell area, vacuole number per cell and percentage of cell area occupied by vacuoles for untreated cells (a, c, e) and cells exposed to 10 μM amiodarone (b, d, f). NR8383 rat macrophage cells (purple triangle), U937 human monocyte-derived macrophage cells (green circles), primary rat macrophages derived from BAL in in vitro culture for 24 h or 48 h (orange diamonds) and primary rat macrophages derived from BAL tested immediately after harvesting from naïve rats after 1 and 7 day timepoints (blue squares). Each data point represents the median value of n = 6 wells per plate. * indicates p < 0.05.