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. 2017 Jun 14;34(12):2517–2531. doi: 10.1007/s11095-017-2190-7

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — In-vitro transport of dendrimers and dextran probes in lung epithelial cells (1a) Permeability of in-vitro Calu-3 cell monolayers showing a plot of P_app (x 10⁻⁶ cm/s) as a function of Stokes diameter, and demonstrating molecular size-dependent transport of dextrans (FD), with an overlay of F-Na permeability. The permeability of the dendrimers, PAMAM3.5 and PAMAM5.5, being considerably greater than expected based on molecular size alone; (1b) Relative permeability of the paracellular probe F-Na and the impact of co-incubation with unlabelled PAMAM1.5, PAMAM3.5 and PAMAM5.5. All data n = 4–6 ± standard deviation. * denotes p < 0.05 compared to control by one-way ANOVA and Newman-Keuls multiple comparison test.