Table II.

Pulmonary Transport Kinetic Parameters for Macromolecular FD and PAMAM Solutes. Data are Mean ± SD, n = 3 Except F-Na (40 μg Dose) Where n = 14. † Denotes Studies Conducted over 60 min

Solute	PAMAM 1.5	PAMAM 3.5		PAMAM 5.5		F-Na		FD4	FD20		FD70
Nominal lung deposited dose	150 nmol	Low dose 20 nmol	High dose 130 nmol	Low dose 23 nmol	High dose 91 nmol	40 μg 100 nmol	160 μg 400 nmol	200 μg 50 nmol	Low dose 200 μg 10 nmol	High dose 2000 μg 100 nmol	200 μg 4 nmol
% dose absorbed at 60 min	20.5 ± 7.5	13.9 ± 1.9	5.1 ± 1.6†	14.5 ± 5.5	8.6 ± 3.4†	75.7 ± 1.4	61.9 ± 8.6††	42.5 ± 8.2	22.4 ± 7.4	20.7 ± 4.1††	8.6 ± 2.5
K in (min −1 )	0.0065 ± 0.0006	0.0032 ± 0.0004	0.0014 ± 0.0005†	0.0031 ± 0.0006	0.0012 ± 0.0002†	0.039 ± 0.008	0.046 ± 0.02††	0.017 ± 0.006	0.0043 ± 0.001	0.0047 ± 0.0002††	0.0021 ± 0.0002
Mw (g.mo1−1)	2935	12,931		52,901		396		3820	20,200		75,090
Hydrodynamic diameter (nm) $	3.3	5.2		7.9		1.0		2.8	6.6		12

^$values taken from {Fritzinger et al. (17) #67}

^†indicates a significant difference (p > 0.05) between the parameters for the two instilled doses

^††no difference (p > 0.05) between the parameters for the two instilled doses