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NLRP3 is required to elicit IL-1β production and to partly inhibit M. pneumoniae growth in vivo. WT and NLRP3 KO C57BL/6 mice were infected with M. pneumoniae (7 log10 CFU) for 2 days and 7 days. IL-1β (A) and IL-6 (B) levels in BALFs from 2-day-infected lungs were measured by ELISA. BALFs from mice at 2 days (C) and 7 days (D) postinfection were also analyzed for quantification of M. pneumoniae genomes by qPCR. *, P < 0.05; ***, P < 0.001.
