TABLE 1.
Competitive indexes for S. Dublin 3246 mutants in miced
| Salmonella strain (n,a group) compared with S. Dublin 3246 | CI |
|---|---|
| S. Dublin ΔbstA (6, group 5) | 1.55 ± 0.55b |
| S. Dublin 3246-C (6, group 6) | 0.71 ± 0.13c |
| S. Dublin 3246/pACY177 (6, group 7) | 0.61 ± 0.52 |
n, number of mice in the experiment. All 6 mice from group 7 survived to the end of the experiment. One animal each from group 5 and group 6 was sacrificed 1 day before the end of the trial (4 days postinfection) (see Table SA1 in the supplemental material). Data for sacrificed mice were also included in the study.
The CI was significantly different from 1.0 (P < 0.05).
The CI was significantly different from that for the corresponding mutant (P < 0.001).
Competition indexes were calculated on the basis of the input (number of CFU per milliliter of inoculum) and output (number of CFU per milliliter of spleen sample) numbers of WT versus mutant bacteria as previously described (10). The results are shown as mean values on the basis of the number of mice tested (indicated in parentheses in the first column). Statistical significance was determined by one-way ANOVA with pairwise comparison of the means.