TABLE 1.
Summary of miRNAs used in this study
| No. | miRNA | Expression in reproductive tract during Chlamydia infection (fold change) | Target(s)/role in fibrogenesis | Reference(s) |
|---|---|---|---|---|
| 1 | miR-15a | Downregulation (∼5) | TGF-βR1, CTGF/prevention | 6, 24 |
| 2 | miR-24 | Downregulation (∼3) | Furin/prevention | 30–32 |
| 2 | miR-27a | Downregulation (∼4) | Sp1, TGF-βR1, SMAD2, Gremlin1/prevention | 25, 26 |
| 3 | miR-29a | Downregulation (∼6) | TGF-β, collagen types I, III, and IV/prevention | 6, 23 |
| 4 | miR-29b | Downregulation (∼6) | Collagen type I, α-SMA, TGF-βR1, SMAD2, Gremlin1/prevention | 6, 49, 50 |
| 5 | miR-101-1 | Downregulation (∼2) | TGF-βR1, fos, KLF6/prevention | 23, 27, 28 |
| 6 | miR-185 | Downregulation (∼2) | TGF-β1, collagen I/prevention | 6, 35 |
| 7 | miR-203 | Downregulation (∼2) | Snail2 (Slug), SMAD3/prevention | 33, 34 |
| 8 | miR-221 | Downregulation (∼3) | Osteopontin/prevention | 36 |
| 9 | miR-9 | Upregulation (∼6) | E-cadherin/SOX7/promotion | 8 |
| 10 | miR-199b | Upregulation (∼3) | Dyrk1a, E-cadherin, claudin/promotion | 38, 39 |