Figure 2.

Whisker‐box plots show the median, quartiles and 95% prediction intervals for the steady‐state concentrations (C_ss) achieved in children receiving different doses and dosing regimens of antiepileptic drugs administered as monotherapy. Shaded area depicts the reference therapeutic range; numbers shown below the bars are percentages of the population with C_ss values outside the reference therapeutic range. See text for details on the population PK models, covariate effects and simulation procedures. CBZ= carbamazepine, CLBZ= clobazam, CLNZ= clonazepam, LMT= lamotrigine, LVT= levetiracetam, OXC= oxcarbazepine, PHB= phenobarbital, PHT= phenytoin, TPM= topiramate, VPA+ valproic acid, ZNS= zonisamide