Table 2.
Patient baseline demographic characteristics used for the simulation scenarios, in which a virtual cohort of patients was treated with one or more antiepileptic drugs
| Population | adults | children |
|---|---|---|
| Age (years) | 18–65, uniformly distributed | 4–14, uniformly distributed |
| Mean weight (kg) | 75 (male) | (Age×3)+7a |
| 65 (female) | ||
| Coefficient of variation on weight | 16% | 10% |
| Dose interval (h) | 12 | 12 |
| Dose | mg day–1 | mg kg–1 day–1 |
| Number of simulated subjects per scenario | 1000 | 1000 |
a
Based on the weight‐by‐age formula proposed by Luscombe & Owens 51