Table 2.
Pharmacokinetic parameters for lesinurad and febuxostat
| Parameter | Febuxostat | Lesinurad | ||
|---|---|---|---|---|
| Estimate | BSV (CV%) | Estimate | BSV (CV%) | |
| CL/F_0 (dl h −1 ) a | 49.3 | 18.3 | 69.9 | 63.4 |
| b_CrCl | 0.142 | NA | 0.322 | NA |
| b_WT | 0.155 | NA | NA | |
| Vc/F_0 (dl) b | 322 | NE | 241 | 12.2 |
| b_WT | NA | 0.511 | NA | |
| Vp/F (dl) | 222 | NE | 83 | 20.5 |
| Q/F (dl h −1 ) | 55.7 | NE | 4.48 | NE |
| Ka (h −1 ) | 13.7 | 176 | 0.69 | 121.7 |
| Tlag (h) | 0.23 | NE | 0.233 | 38.9 |
BSV, between‐subject variability; CL/F, apparent clearance; CrCl, creatinine clearance rate; CV%, percentage coefficient of variation; Ka, first‐order absorption; NA, not applicable; NE, not estimated; Q/F, intercompartmental clearance rate; Tlag, absorption time‐lag; Vc/F, volume of the central compartment; Vp/F, volume of the peripheral compartment; WT, individual body weight (kg)
Febuxostat: CL/F = CL/F_0 + b_CrCl*CrCl + b_WT*WT; Lesinurad: CL/F = CL/F_0 * (CrCl/87)^b_CrCl
Lesinurad: VC/F = VC/F_0 * (WT/70)^b_WT