Table 5.
Geometric mean (CV%) pharmacokinetic parameters from the two‐compartmental model of single ascending and multiple‐dose cohorts
| CL 1 (ml h –1 kg –1 ) | CL 2 (ml h –1 kg –1 ) | V 1 (ml kg –1 ) | V 2 (ml kg –1 ) | α (1 h –1 ) | β (h –1 ) | |
|---|---|---|---|---|---|---|
| SAD | 115 (2.3) | 50.2 (23.0) | 110 (10.9) | 86.6 (12.4) | 1.77 (18.7) | 0.34 (12.1) |
| MD | 121 (4.1) | 40.6 (33.2) | 159 (10.5) | 130.9 (25.3) | 1.17 (17.9) | 0.20 (25.2) |
Data are presented as the geometric mean (CV%)
α, elimination rate from the central compartment; β, elimination rate from the peripheral compartment; CL1, clearance from the central compartment; CL2, clearance from the peripheral compartment; CV%, coefficient of variation; MD, multiple‐dose cohort; SAD, single ascending dose cohort; V1, volume of distribution of the central compartment; V2, volume of distribution of the peripheral compartment