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. 2017 Sep 22;5(1):99–100.e7. doi: 10.1016/j.jcmgh.2017.09.006

Figure 2.

Figure 2

CRTH2 antagonist pretreatment reduces the accumulation of both eosinophils and mast cells in Aspergillus-induced experimental EoE. CRTH2 antagonist pretreatment significantly reduced the number of (D) eosinophils and (H) mast cells relative to (C and H) Aspergillus-challenged mice that were not pretreated. (A and B) No eosinophils and few (E and F) baseline mast cells were detected in sections from mice treated with saline or saline + CRTH2 antagonist. Data are expressed as means ± SD (n = 8–10 mice/group). EP, epithelial mucosa; LP, lamina propria; LU, lumen; MP, muscularis propria.