Supplementary Figure 4.

(A) BALB/c mice challenged with Aspergillus were treated with a CRTH2 antagonist (OC000459) as per the protocol of experimental EoE. Morphometric quantification indicated that CRTH2-antagonist treatment reduced the (B) number of eosinophils and (C) mast cells that accumulate in the esophagus of Aspergillus-challenged mice relative to the untreated Aspergillus-challenged control mice. The levels of eosinophils and mast cells in the esophageal sections are expressed as eosinophils/mm² and mast cells/mm², respectively. Data are expressed as means ± SD (n = 8–10 mice/group).