Table 1.
Characteristics of the studies included in the meta-analysis
| First author | Country (Ethnicity) | Case/Control | Cases | Control | MAFs | HWE | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotypes | Alleles | Genotypes | Alleles | |||||||||||
| Pvu II T>C | CC | TC | TT | C | T | CC | TC | TT | C | T | ||||
| Bergink 2003 (12) | Netherlands (Caucasian) | 1483/687 | 434 | 737 | 312 | 1605 | 1361 | 225 | 333 | 129 | 783 | 591 | 0.430 | 0.767 |
| Jin 2004 (13) | Korea (Asian) | 151/397 | 61 | 68 | 22 | 190 | 112 | 152 | 183 | 62 | 487 | 307 | 0.386 | 0.575 |
| Xue 2004 (14) | China (Asian) | 55/176 | 17 | 23 | 15 | 57 | 53 | 57 | 87 | 32 | 201 | 151 | 0.429 | 0.905 |
| Tian 2009 (15) | China (Asian) | 38/40 | 16 | 15 | 7 | 47 | 29 | 15 | 16 | 9 | 46 | 34 | 0.425 | 0.250 |
| Yang 2009 (16) | China (Asian) | 41/40 | 14 | 17 | 10 | 45 | 37 | 12 | 23 | 5 | 47 | 33 | 0.412 | 0.238 |
| Riancho a 2010 (17) | UK (Caucasian) | 445/862 | 77 | 245 | 123 | 399 | 491 | 167 | 442 | 253 | 776 | 948 | 0.549 | 0.292 |
| Riancho b 2010 (17) | Spain (Caucasian) | 272/802 | 53 | 140 | 79 | 246 | 298 | 179 | 394 | 229 | 752 | 852 | 0.531 | 0.699 |
| Riancho c 2010 (17) | Spain (Caucasian) | 254/473 | 46 | 143 | 65 | 235 | 273 | 80 | 217 | 176 | 377 | 569 | 0.601 | 0.349 |
| Borgonio-Cuadra 2012 (18) | Mexico (Mixed) | 115/117 | 52 | 49 | 14 | 153 | 77 | 51 | 50 | 16 | 152 | 82 | 0.350 | 0.507 |
| Dai 2014 (19) | China (Asian) | 469/514 | 167 | 217 | 85 | 551 | 387 | 198 | 242 | 74 | 638 | 390 | 0.379 | 0.996 |
| Liu 2014 (20) | China (Asian) | 98/196 | 30 | 41 | 27 | 101 | 95 | 63 | 97 | 36 | 223 | 169 | 0.431 | 0.900 |
| XbaI A>G | AA | GA | GG | A | G | AA | GA | GG | A | G | ||||
| Bergink (2003) (12) | Netherlands (Caucasian) | 1483/687 | 643 | 682 | 158 | 1968 | 998 | 372 | 263 | 52 | 1007 | 367 | 0.267 | 0.560 |
| Jin 2004 (14) | Korea (Asian) | 151/397 | 98 | 49 | 4 | 245 | 57 | 256 | 126 | 15 | 638 | 156 | 0.196 | 0.917 |
| Xue 2004 (14) | China (Asian) | 55/176 | 21 | 24 | 10 | 66 | 44 | 40 | 82 | 54 | 162 | 190 | 0.539 | 0.408 |
| Tian 2009 (15) | China (Asian) | 38/40 | 18 | 16 | 4 | 52 | 24 | 6 | 21 | 13 | 33 | 47 | 0.587 | 0.598 |
| Yang 2009 (16) | China (Asian) | 41/40 | 28 | 11 | 2 | 67 | 15 | 24 | 13 | 3 | 61 | 19 | 0.237 | 0.516 |
| Borgonio-Cuadra 2012 (18) | Mexico (Mixed) | 115/117 | 70 | 41 | 4 | 181 | 49 | 62 | 47 | 8 | 171 | 63 | 0.269 | 0.821 |
| Dai 2014 (19) | China (Asian) | 469/514 | 288 | 152 | 29 | 728 | 210 | 348 | 155 | 19 | 851 | 193 | 0.184 | 0.736 |
| Liu 2014 (20) | China (Asian) | 98/196 | 36 | 43 | 19 | 115 | 81 | 49 | 92 | 55 | 190 | 202 | 0.515 | 0.398 |
| BtgI G>A | GG | AG | AA | G | A | GG | GA | AA | G | A | ||||
| Jin 2004 (13) | Korea (Asian) | 151/397 | 84 | 57 | 10 | 225 | 77 | 257 | 122 | 18 | 636 | 158 | 0.199 | 0.472 |
| Jiao 2007 (21) | China (Asian) | 76/118 | 5 | 56 | 15 | 66 | 86 | 16 | 97 | 5 | 129 | 107 | 0.453 | <0.001 |
| Tawonsawatruk 2009 (22) | Thailand (Asian) | 104/104 | 62 | 37 | 5 | 131 | 17 | 63 | 37 | 4 | 163 | 45 | 0.216 | 0.615 |