. 2017 Nov;5(6):351–362.

Table 4.

The meta-analysis of ESRα XbaI A>G polymorphism and KOA risk

Subgroup	Study Number	Genetic Model	Type of Model	Heterogeneity		Odds ratio			Publication Bias

				I² (%)	P_H	OR	95% CI	Z_test	P_OR	P_Beggs	P_Eggers
XbaI A>G
Overall
	8	G vs. A	Random	86.08	<0.001	1.225	0.896-1.675	1.272	0.203	0.035	0.003
	8	GA vs. AA	Random	81.90	<0.001	1.033	0.537-1.986	0.097	0.922	0.901	0.366
	8	GG vs. AA	Random	80.80	<0.001	1.572	0.812-3.041	1.343	0.179	0.265	0.023
	8	GG+GA vs. AA	Random	73.93	<0.001	1.248	0.719-2.167	0.787	0.431	0.536	0.148
	8	GG vs. GA+AA	Random	82.50	<0.001	1.252	0.871-1.801	1.213	0.225	0.009	<0.001
Caucasian
	1	G vs. A	Ref.	0.00	1.000	0.719	0.624-0.828	-4.569	<0.001	NA	NA
	1	GA vs. AA	Ref.	0.00	1.000	0.853	0.605-1.204	-0.903	0.367	NA	NA
	1	GG vs. AA	Ref.	0.00	1.000	0.569	0.406-0.798	-3.268	0.001	NA	NA
	1	GG+GA vs. AA	Ref.	0.00	1.000	0.687	0.495-0.953	-2.250	0.024	NA	NA
	1	GG vs. GA+AA	Ref.	0.00	1.000	0.648	0.540-0.777	-4.673	<0.001	NA	NA
Asian
	6	G vs. A	Random	84.00	<0.001	1.364	0.909-2.048	1.500	0.134	0.132	0.045
	6	GA vs. AA	Random	86.23	<0.001	1.042	0.388-2.798	0.082	0.934	0.707	0.228
	6	GG vs. AA	Random	75.71	0.001	1.895	0.857-4.189	1.578	0.114	0.452	0.241
	6	GG+GA vs. AA	Random	74.31	0.002	1.380	0.659-2.891	0.853	0.394	1.000	0.600
	6	GG vs. GA+AA	Random	77.89	<0.001	1.461	0.920-2.321	1.608	0.108	0.060	0.012
Mixed
	1	G vs. A	Ref.	0.00	1.000	1.361	0.887-2.088	1.412	0.158	NA	NA
	1	GA vs. AA	Ref.	0.00	1.000	1.745	0.489-6.220	0.858	0.391	NA	NA
	1	GG vs. AA	Ref.	0.00	1.000	2.258	0.648-7.865	1.279	0.201	NA	NA
	1	GG+GA vs. AA	Ref.	0.00	1.000	2.037	0.596-6.961	1.134	0.257	NA	NA
	1	GG vs. GA+AA	Ref.	0.00	1.000	1.380	0.819-2.325	1.210	0.226	NA	NA