Table 5.

The meta-analysis of ESRα BtgI G>A polymorphism and KOA risk

Polymorphism	Study Number	Genetic Model	Type of Model	Heterogeneity		Odds ratio				Publication Bias
				I2 (%)	PH	OR	95% CI	Ztest	POR	PBeggs	PEggers
BtgI G>A
	3	A vs. G	Fixed	32.61	0.227	0.639	0.515-0.793	-4.064	<0.001	0.296	0.294
	3	AG vs. GG	Fixed	59.94	0.082	0.526	0.291-0.953	-2.117	0.034	1.000	0.865
	3	AA vs. GG	Fixed	60.89	0.078	0.448	0.240-0.838	-2.513	0.012	0.296	0.651
	3	AA+AG vs. GG	Fixed	55.50	0.106	0.469	0.264-0.833	-2.583	0.010	1.000	0.894
	3	AA vs. GA+GG	Fixed	0.00	0.390	0.729	0.540-0.986	-2.054	0.040	1.000	0.790
By HWE
	2	A vs. G	Fixed	66.30	0.085	0.640	0.496-0.825	-3.444	0.001	NA	NA
	2	AG vs. GG	Fixed	0.00	0.952	0.830	0.406-1.698	-0.510	0.610	NA	NA
	2	AA vs. GG	Fixed	0.00	0.719	0.635	0.316-1.275	-1.277	0.202	NA	NA
	2	AA+AG vs. GG	Fixed	0.00	0.833	0.700	0.352-1.388	-1.022	0.307	NA	NA
	2	AA vs. GA+GG	Fixed	0.00	0.321	0.762	0.556-1.043	-1.695	0.090	NA	NA