Table 1.
Regional analysis for relaxation rate (R2) for all RG2 tumor-bearing rats that underwent coinfusion of TmDOTP5− and probenecid (n = 5). See Figure 3(a) for details. R2 was measured inside the MRI-defined tumor core (see Figure S2), at the tumor edge (regions 1 mm outside the tumor boundary), and in the healthy/nontumor tissue before and after the infusion of SPIO-NPs. Data shown are mean and standard deviation (SD).
| R 2 | Intrinsic | TmDOTP5− | TmDOTP5− + SPIO-NPs | |||
|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | |
| Tumor core | 22.5 | 2.1 | 24.7 | 2.5 | 32.7 | 5.2 |
| Tumor's edge | 22.7 | 4.0 | 23.7 | 4.4 | 28.6 | 7.9 |
| Nontumor tissue | 23.8 | 3.8 | 23.2 | 3.4 | 27.3 | 3.7 |