Table 2.
Influence of BDME on blood parameters after vincristine-induced neuropathic pain in rats.
| Dose (mg/kg) |
Haemoglobin (g/dl) |
RBC (million/µl) |
Hematocrit (%) |
WBC (109/L) |
Platelet count (109/L) |
|
|---|---|---|---|---|---|---|
| Normal control | - | 12.45 ± 0.25 | 7.06 ± 0.19 | 40.38 ± 1.11 | 7.58 ± 0.28 | 831.75 ± 34.48 |
| Vincristine + vehicle | - | 7.15 ± 0.39γ | 3.90 ± 0.19γ | 25.93 ± 1.03γ | 1.68 ± 0.14β | 481.25 ± 26.80β |
| Vincristine + Morphine | 5 | 11.60 ± 0.35c | 6.05 ± 0.52αc | 35.10 ± 1.27αb | 9.00 ± 0.52c | 1074.00 ± 15.01αc |
| Vincristine + BDME | 500 | 12.65 ± 0.55c | 6.87 ± 0.14c | 39.68 ± 1.16c | 8.13 ± 0.49c | 1001.00 ± 58.87c |
RBC: red blood cell; WBC: white blood cell; Hb: haemoglobin. Each value represents the mean ± ESM for six animals and analyzed by two-way ANOVA followed by Tukey post hoc test. αp < 0.05; βp < 0.01; γp < 0.001 statistically significant compared to normal control. cp < 0.001 statistically significant compared to vincristine and vehicle. bp < 0.01.