Table 3.
Effect of BDME on serum parameters in vincristine induced neuropathic pain in rats.
| Dose (mg/kg) |
ALP (U/l) |
ALT (U/l) |
AST (U/l) |
Creatinine (mg/dl) |
|
|---|---|---|---|---|---|
| Normal control | - | 72.80 ± 1.83 | 41.20 ± 2.56 | 44.00 ± 2.03 | 0.41 ± 0.03 |
| Vincristine + vehicle | - | 481.00 ± 9.68γ | 182.00 ± 7.23γ | 136.00 ± 3.03γ | 0.87 ± 0.01γ |
| Vincristine + Morphine | 5 | 186.00 ± 27.70γc | 85.00 ± 4.18γc | 97.00 ± 3.03γc | 0.58 ± 0.03γc |
| Vincristine + BDME | 500 | 87.00 ± 2.68c | 48.40 ± 2.16c | 74.40 ± 2.23γc | 0.41 ± 0.03c |
ALP: alkaline phosphatase; AST: aminotransferase; ALT: alanine aminotransferase. Each value represents the mean ± ESM for six animals and analyzed by two-way ANOVA followed by Tukey post hoc test, γp < 0.001 when compared to normal control, cp < 0.001 when compared to vincristine and vehicle.