Fig. 1.

Impact of ELS on growth and maturation of the murine hippocampus. (A) Across early postnatal development there is a significant decline in rates of cell proliferation and differentiation. (B) Across this same period there is a gradual increase in makers of cellular and circuit maturation including myelination, synaptic differentiation, and interneuron integration. Across these measures, we find that ELS (dashed) leads to a more rapid silencing of neurogenesis and an earlier onset and completion of maturational processes in the hippocampus of the mouse.