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. 2017 Dec 15;11:390. doi: 10.3389/fncel.2017.00390

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Copyright © 2017 Juzekaeva, Nasretdinov, Gainutdinov, Sintsov, Mukhtarov and Khazipov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Elevation of extracellular potassium accelerates the onset of anoxic depolarization. (A) OIS from L4 (top trace) and nearby L4 DC-coupled LFP (bottom trace) during superfusion with ACSF with elevated (from 3.5 to 8.5 mM) potassium concentration and after OGD induction. (B) Corresponding microphotograph (left) and OIS snapshots at different time points after OGD induction. (C) Group data on AD onsets in control ACSF (n = 17) and in the ACSF with potassium concentration elevated to 8.5 mM (n = 13). Each white circle corresponds to one slice and black circles show the mean ± SE. Note that AD onset is accelerated almost two-fold after elevation of extracellular potassium concentration. ^***p < 0.001.