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. 2017 Dec 13;8:902. doi: 10.3389/fphar.2017.00902

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Copyright © 2017 Huang, Tsai, Chen, Kuo, Kuo, Lee, Chen, Wu, Chuang, Cheng, Lin, Leung, Chang and Cheung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Upregulation of HDAC2 correlates with poor overall and relapse-free survival in patients with ER⁺, hormone therapy-treated breast cancer. (A,B) Expression of various HDAC isoforms in MCF7 and MCF7-TamC3 cells was determined by Western blotting and qPCR analysis. Both “^∗” and “^∗∗” denote a statistical significance (P < 0.05 and P < 0.01, respectively) between the testing groups. (C) Kaplan–Meier survival estimates of high (red line) or low (black line) HDAC2 and HDAC5 expression in ER⁺ tamoxifen/endocrine therapy-treated breast cancer. Analysis was performed using the online database and web tool (Kaplan Meier plotter). (D) ROC analysis of HDAC2 for 5-year relapse-free survival on ER⁺ tamoxifen-treatment breast cancer patients.