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. 2017 Dec 13;8:902. doi: 10.3389/fphar.2017.00902

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Copyright © 2017 Huang, Tsai, Chen, Kuo, Kuo, Lee, Chen, Wu, Chuang, Cheng, Lin, Leung, Chang and Cheung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HDAC2 positively regulates the expression of Sp1 and negatively regulates the expression of p53 in ER⁺ breast cancer cells. (A) Expression of Sp1 and p53 in MCF7 and MCF7-TamC3 cells was determined by Western blotting. (B) Expression of survivin at the transcriptional level in MCF7 and MCF7-TamC3 cells was determined by qPCR. “^∗∗” denotes a statistical significance (P < 0.01) between the testing groups. (C) Breast cancer cells were transfected with either scramble siRNA or HDAC2 siRNA for 24–48 h (depending on the target knockdown efficiency in different cell lines). Expression of Sp1 and p53 was determined by Western blotting. (D) Breast cancer cells were transfected with either scramble siRNA or HDAC2 siRNA for 48 h and expression of survivin was determined by qPCR. “^∗” and ^∗∗∗” denote a statistical significance (P < 0.05 and P < 0.001, respectively) between the testing groups.