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. Author manuscript; available in PMC: 2017 Dec 20.
Published in final edited form as: Nature. 2017 May 10;545(7654):299–304. doi: 10.1038/nature22308

Figure 5. Conversion of a Gram-positive-only antibacterial into a compound that accumulates in E. coli and kills Gram-negative bacteria.

Figure 5

6DNM, 6DNM-NH3 and ciprofloxacin were evaluated against a panel of Gram-positive and Gram-negative organisms. E. coli MG1655 accumulation listed in nmol per 1012 CFUs. MIC values were determined using the micro-dilution broth method as outlined by the Clinical and Laboratory Standards Institute (http://clsi.org/) and are listed in μg ml−1. All experiments were performed in biological triplicate. Strains are listed in the Methods. The s.e.m. is reported for accumulation values.