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. 2017 Dec 15;8:347. doi: 10.3389/fendo.2017.00347

Figure 6.

Figure 6

(A) Representative electron micrographs of mitochondria in the study subjects (Original magnification 10,000×, print magnification 49,400×@7.in 400 nm scale). White arrows represent mitochondria. The panels indicating (a) Controls (healthy and larger mitochondria) (GP-I); (b) Prediabetic subjects (healthy and larger mitochondria) (GP-II); (c) NDT2DM patients (GP-III), and (d) ADT2DM patients (GP-IV). Healthy mitochondria were characterized by oval or spherical shape, well-defined cristae and dense matrix, while mitochondria in type 2 diabetes mellitus (T2DM) subjects were smaller in size, rounded and with degenerated matrix (B) bar diagram displaying the total mitochondrial area per cell in all the study groups (C) bar graph represents the percentage of distorted mitochondria in controls (GP-I); prediabetic subjects (GP-II); NDT2DM patients (GP-III); ADT2DM patients, who were randomly selected with similar clinical and biochemical profile in each group (n = 3). Values are expressed in mean ± SD; (* = vs. GP-I) (# = vs. GP-II), *p < 0.05; **p < 0.01, ***p < 0.001; ##p < 0.01; ###p < 0.001.