Table 2.
Sensitivity and specificity of different mitophagy markers at HbA1C cutoff 7% by receiver operating characteristic (ROC) analysis.
| Variables | Cutoff value of HbA1C (%) | AUC (95% CI) (P value) | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|
| Mitofusin2 (MFN2) mRNA levels | 7 | 1.000 (1.000–1.000) (p < 0.001) | 100 | 90 |
| NIX mRNA levels | 7 | 0.991 (0.971–1.012) (p < 0.0001) | 95 | 90 |
| PARKIN mRNA levels | 7 | 0.781 (0.628–0.934) (p < 0.002) | 80 | 70 |
| PINK1 mRNA levels | 7 | 0.996 (0.985–1.000) (p < 0.0001) | 100 | 86 |
| LC3-II mRNA levels | 7 | 1.000 (1.000–1.000) (p < 0.0001) | 100 | 90 |
| Lysosome-associated membrane protein-2 (LAMP-2) mRNA levels | 7 | 0.714 (0.547–0.880) (p < 0.02) | 75 | 65 |
AUC, area under curve.