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. 2017 Aug 30;45(18):10751–10763. doi: 10.1093/nar/gkx744

Figure 1.

Figure 1.

AtPolIs are family-A DNA polymerases (DNAPs) with canonical editing and polymerization domains. (A) Domain organization of AtPolIs in comparison to KF-DNAP I and Klen-Taq. AtPolIs contain a conserved 3′-5′ exonuclease and polymerization domains. The mitochondrial targeting sequence (MTS) of the dual targeting element is colored in gold and the predicted N-terminal disorder sequence is colored in cyan. (B) Homology model of AtPolIB in comparison to the crystal structure of Klen-Taq in complex with dsDNA and incoming nucleotide (upper part). Homology model of AtPolIB in comparison to the crystal structure of the KF-DNAP I with dsDNA and extruded 3′ single-stranded DNA in the exonuclease domain (bottom part). In both models the primer strand is colored in magenta and the template strand in gold. The incoming dNTP and the 3′ single-stranded DNA is black colored and in a ball-stick representation. The three unique amino acid insertions in POPs are colored in gray, blue and yellow.